Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

Afkhami, Sam; D’Agostino, Michael R.; Zhang, Ali; Stacey, Hannah D.; Marzok, Art; Kang, Alisha; Singh, Ramandeep; Bavananthasivam, Jegarubee; Ye, Gluke; Luo, Xiangqian; Wang, Fuan; Ang, Jann C.; Zganiacz, Anna; Sankar, Uma; Kazhdan, Natallia; Koenig, Joshua F. E.; Phelps, Allyssa; Gameiro, Steven F.; Tang, Shangguo; Jordana, Manel; Wan, Yonghong; Mossman, Karen L.; Jeyanathan, Mangalakumari; Gillgrass, Amy; Medina, Maria Fe C.; Smaill, Fiona; Lichty, Brian D.; Miller, Matthew S.; Xing, Zhou

doi:10.1016/j.cell.2022.02.005

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Afkhami, S., D’Agostino, M. R., Zhang, A., Stacey, H. D., Marzok, A., & Kang, A., et al. (2022). Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2. Cell.
Added by: Dr. Enrique Feoli (11/02/2022, 17:27) Last edited by: Dr. Enrique Feoli (11/02/2022, 18:59)

Resource type: Journal Article
DOI: 10.1016/j.cell.2022.02.005
ID no. (ISBN etc.): 0092-8674, 1097-4172
BibTeX citation key: Afkhami2022
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Categories: BioAcyl Corp, BioAcyl Corp
Subcategories: Covid-19 adenoviral vectors, COVID-19 Vaccines
Creators: Afkhami, Ang, Bavananthasivam, D’Agostino, Gameiro, Gillgrass, Jeyanathan, Jordana, Kang, Kazhdan, Koenig, Lichty, Luo, Marzok, Medina, Miller, Mossman, Phelps, Sankar, Singh, Smaill, Stacey, Tang, Wan, Wang, Xing, Ye, Zganiacz, Zhang
Collection: Cell

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Abstract

The emerging SARS-CoV-2 variants of concern (VOC) threaten the effectiveness of current COVID-19 vaccines administered intramuscularly and designed to only target the spike protein. There is a pressing need to develop next-generation vaccine strategies for broader and long-lasting protection. Using adenoviral vectors (Ad) of human and chimpanzee origin, we evaluated Ad-vectored trivalent COVID-19 vaccines expressing Spike-1, Nucleocapsid and RdRp antigens in murine models. We show that single-dose intranasal immunization, particularly with chimpanzee Ad-vectored vaccine, is superior to intramuscular immunization in induction of the tripartite protective immunity consisting of local and systemic antibody responses, mucosal tissue-resident memory T cells and mucosal trained innate immunity. We further show that intranasal immunization provides protection against both the ancestral SARS-CoV-2 and two VOC, B.1.1.7 and B.1.351. Our findings indicate that respiratory mucosal delivery of Ad-vectored multivalent vaccine represents an effective next-generation COVID-19 vaccine strategy to induce all-around mucosal immunity against current and future VOC.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli

Notes

Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli