BioAcyl Corp
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Uematsu, S., Fujimoto, K., Jang, M. H., Yang, B.-G., Jung, Y.-J., & Nishiyama, M., et al. (2008). Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing toll-like receptor 5. Nature Immunology, 9(77), 769–776. Added by: Dr. Enrique Feoli (28/01/2022, 15:38) Last edited by: Dr. Enrique Feoli (28/01/2022, 15:42) |
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| Resource type: Journal Article DOI: 10.1038/ni.1622 ID no. (ISBN etc.): 1529-2916 BibTeX citation key: Uematsu2008 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Inmunidad de mucosas Creators: Akira, Fujimoto, Ishii, Jang, Jung, Kiyono, Miyasaka, Nishiyama, Sato, Tsujimura, Uematsu, Yamamoto, Yang, Yokota Collection: Nature Immunology |
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| Abstract |
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The intestinal cell types responsible for defense against pathogenic organisms remain incompletely characterized. Here we identify a subset of CD11chiCD11bhi lamina propria dendritic cells (LPDCs) that expressed Toll-like receptor 5 (TLR5) in the small intestine. When stimulated by the TLR5 ligand flagellin, TLR5+ LPDCs induced the differentiation of naive B cells into immunoglobulin A–producing plasma cells by a mechanism independent of gut-associated lymphoid tissue. In addition, by a mechanism dependent on TLR5 stimulation, these LPDCs promoted the differentiation of antigen-specific interleukin 17–producing T helper cells and type 1 T helper cells. Unlike spleen DCs, the LPDCs specifically produced retinoic acid, which, in a dose-dependent way, supported the generation and retention of immunoglobulin A–producing cells in the lamina propria and positively regulated the differentiation interleukin 17–producing T helper cells. Our findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine.
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