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Nie, C., Pouyan, P., Lauster, D., & others. (2021). Polysulfates block sars-cov-2 uptake through electrostatic interactions. Angew. Chem. Int. Ed. 60(29), 15870–15878. 
Added by: Dr. Enrique Feoli (17/01/2022, 11:55)   Last edited by: Dr. Enrique Feoli (17/01/2022, 16:33)
Resource type: Journal Article
DOI: 10.1002/anie.202102717
ID no. (ISBN etc.): 1433-7851
BibTeX citation key: Nie2021
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 Categories: BioAcyl Corp
Subcategories: Polysulfate polianions
Creators: Lauster, Nie, others, Pouyan
Collection: Angew. Chem. Int. Ed.		 Views: 2/278
Abstract
Negatively charged polysulfates can bind to the positively charged patches of RBD of SARS-CoV-2 and block viral interaction with host cells for infection inhibition. The synthetic linear polyglycerol sulfate (LPGS) exhibits higher virus inhibitory activity than heparin, but lower anticoagulant activity. Therefore, it is considered to be a promising substitute for heparin in clinical applications.
  
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