BioAcyl Corp
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Cervia, C., Nilsson, J., Zurbuchen, Y., & others. (2021). Systemic and mucosal antibody responses specific to sars-cov-2 during mild versus severe covid-19. J. Allergy Clin. Immunol. 147(2), 545–557.e9. Added by: Dr. Enrique Feoli (13/01/2022, 08:53) Last edited by: Dr. Enrique Feoli (13/01/2022, 08:55) |
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| Resource type: Journal Article DOI: 10.1016/j.jaci.2020.10.040 ID no. (ISBN etc.): 0091-6749 BibTeX citation key: Cervia2021 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Cross immunity Creators: Cervia, Nilsson, others, Zurbuchen Collection: J. Allergy Clin. Immunol. |
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| Abstract |
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{BackgroundWhereas severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody tests are increasingly being used to estimate the prevalence of SARS-CoV-2 infection, the determinants of these antibody responses remain unclear.ObjectivesOur aim was to evaluate systemic and mucosal antibody responses toward SARS-CoV-2 in mild versus severe coronavirus disease 2019 (COVID-19) cases.MethodsUsing immunoassays specific for SARS-CoV-2 spike proteins, we determined SARS-CoV-2{textendash}specific IgA and IgG in sera and mucosal fluids of 2 cohorts, including SARS-CoV-2 PCR-positive patients (n = 64) and PCR-positive and PCR-negtive health care workers (n = 109).ResultsSARS-CoV-2{textendash}specific serum IgA titers in patients with mild COVID-19 were often transiently positive, whereas serum IgG titers remained negative or became positive 12 to 14 days after symptom onset. Conversely, patients with severe COVID-19 showed a highly significant increase of SARS-CoV-2{textendash}specific serum IgA and IgG titers after symptom onset. Very high titers of SARS-CoV-2{textendash}specific serum IgA were correlated with severe acute respiratory distress syndrome. Interestingly, some health care workers with negative SARS-CoV-2{textendash}specific serum antibody titers showed SARS-CoV-2{textendash}specific IgA in mucosal fluids with virus-neutralizing capacity in some cases. SARS-CoV-2{textendash}specific IgA titers in nasal fluids were inversely correlated with age.ConclusionsSystemic antibody production against SARS-CoV-2 develops mainly in patients with severe COVID-19, with very high IgA titers seen in patients with severe acute respiratory distress syndrome, whereas mild disease may be associated with transient production of SARS-CoV-2{textendash}specific antibodies but may stimulate mucosal SARS-CoV-2{textendash}specific IgA secretion.}
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