Inflammation and metabolic disorders

Hotamisligil, Gifmmodeddotoelse"ofikhan S.

doi:10.1038/nature05485

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BioAcyl Corp

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Hotamisligil, G. S. (2006). Inflammation and metabolic disorders. Nature, 444(7121), 860–867.
Added by: Dr. Enrique Feoli (18/02/2021, 22:26) Last edited by: Dr. Enrique Feoli (18/02/2021, 22:27)

Resource type: Journal Article
DOI: 10.1038/nature05485
ID no. (ISBN etc.): 1476-4687
BibTeX citation key: Hotamisligil2006
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Categories: BioAcyl Corp
Subcategories: Immunometabolism
Creators: Hotamisligil
Collection: Nature

Views: 1/283

Abstract

Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.