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Goldman, A. W., Burmeister, Y., Cesnulevicius, K., Herbert, M., Kane, M., & Lescheid, D., et al. (2015). Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity? Frontiers in physiology, 6, 225. Added by: Dr. Enrique Feoli (16/06/2020, 02:32) Last edited by: Dr. Enrique Feoli (06/04/2024, 12:14) |
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| Resource type: Journal Article DOI: 10.3389/fphys.2015.00225 ID no. (ISBN etc.): 1664-042X BibTeX citation key: Goldman2015 View all bibliographic details  |
Categories: Mendeley Subcategories: Bioregulatory systems medicine Creators: Berman, Burmeister, Cesnulevicius, Goldman, Herbert, Kane, Lescheid, McCaffrey, Schultz, Seilheimer, Smit, St Laurent Collection: Frontiers in physiology |
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| Abstract |
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Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology and genomics, and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease. This article introduces the formal incorporation of these scientific and clinical elements into a cohesive theoretical model of the BrSM approach. The authors review this integrated body of knowledge and discuss how the emergent conceptual model offers the medical field a new avenue for extending the armamentarium of current treatment and healthcare, with the ultimate goal of improving population health. medical care is currently estimated to account for only 10% of health outcomes, while as much as 80% are influenced by environmental and lifestyle factors (McGinnis et al., 2002 Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
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Beyond these pathological distinctions, participants understood inflammation as practically relevant to treatment in two main ways. The inflammatory system is considered the target for stimulating or optimizing disease resolution. Desconocimiento de imflamación. The bidirectional communication using inflammatory pathways between a cell and its microenvironment, functions as a homeostatic control mechanism for many tissues. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |