BioAcyl Corp
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Ariotti, S., Hogenbirk, M. A., Dijkgraaf, F. E., & others. (2014). Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert. Science, 346(6205), 101–105. Added by: Dr. Enrique Feoli (15/02/2021, 00:16) Last edited by: Dr. Enrique Feoli (15/10/2023, 17:34) |
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| Resource type: Journal Article DOI: 10.1126/science.1254803 ID no. (ISBN etc.): 0036-8075 BibTeX citation key: Ariotti2014 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp, BioAcyl Corp Subcategories: Innate Immunity, Network Medicine, Tcell types Cell-mediated effector immunity Creators: Ariotti, Dijkgraaf, Hogenbirk, others Collection: Science |
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| Abstract |
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After an infection, pathogen-specific tissue-resident memory T cells (TRM cells) persist in nonlymphoid tissues to provide rapid control upon reinfection, and vaccination strategies that create TRM cell pools at sites of pathogen entry are therefore attractive. However, it is not well understood how TRM cells provide such pathogen protection. Here, we demonstrate that activated TRM cells in mouse skin profoundly alter the local tissue environment by inducing a number of broadly active antiviral and antibacterial genes. This {textquotedblleft}pathogen alert{textquotedblright} allows skin TRM cells to protect against an antigenically unrelated virus. These data describe a mechanism by which tissue-resident memory CD8+ T cells protect previously infected sites that is rapid, amplifies the activation of a small number of cells into an organ-wide response, and has the capacity to control escape variants.
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