Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

Hotamisligil, G. S.; Shargill, N. S.; Spiegelman, B. M.

doi:10.1126/science.7678183

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Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993). Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science, 259(5091), 87–91.
Added by: Dr. Enrique Feoli (14/02/2021, 22:19) Last edited by: Dr. Enrique Feoli (14/02/2021, 22:20)

Resource type: Journal Article
DOI: 10.1126/science.7678183
ID no. (ISBN etc.): 0036-8075
BibTeX citation key: Hotamisligil1993
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Categories: BioAcyl Corp
Subcategories: Network Medicine
Creators: Hotamisligil, Shargill, Spiegelman
Collection: Science

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Abstract

Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-alpha messenger RNA expression was observed in adipose tissue from four different rodent models of obesity and diabetes. TNF-alpha protein was also elevated locally and systemically. Neutralization of TNF-alpha in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. These results indicate a role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity.