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Moutsopoulos, N. M., & Konkel, J. E. (2018). Tissue-Specific Immunity at the Oral Mucosal Barrier. Trends Immunol. 39(4), 276–287. Added by: Dr. Enrique Feoli (28/01/2021, 17:56) Last edited by: Dr. Enrique Feoli (20/04/2021, 10:12) |
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| Resource type: Journal Article DOI: 10.1016/j.it.2017.08.005 ID no. (ISBN etc.): 1471-4906 BibTeX citation key: Moutsopoulos2018 View all bibliographic details  |
Categories: BioAcyl Corp, Zotero Subcategories: Inmunidad de mucosas Creators: Konkel, Moutsopoulos Collection: Trends Immunol. |
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| Abstract |
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Highlights Unique signals tailor immune functionality at the gingiva compared to other barrier sites. Ongoing damage from mastication is a tissue-specific cue that trains immune function at the gingiva. The oral microbiome provides key signals for the regulation of oral innate defenses. Dysbiosis of the oral microbiome triggers the inflammatory disease periodontitis at the gingiva. At the gingiva, a specialized immune cell network polices this dynamic barrier. Better understanding of immune cell training and function at the gingival barrier will support the development of barrier-targeted immune therapies. The oral mucosal barrier is constantly exposed to a plethora of triggers requiring immune control, including a diverse commensal microbiome, ongoing damage from mastication, and dietary and airborne antigens. However, how these tissue-specific cues participate in the training of immune responsiveness at this site is minimally understood. Moreover, the mechanisms mediating homeostatic immunity at this interface are not yet fully defined. Here we present basic aspects of the oral mucosal barrier and discuss local cues that may modulate and train local immune responsiveness. We particularly focus on the immune cell network mediating immune surveillance at a specific oral barrier, the gingiva {textendash} a constantly stimulated and dynamic environment where homeostasis is often disrupted, resulting in the common inflammatory disease periodontitis.
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| Notes |
Figure 1The Oral and Gingival Barrier. The oral mucosa is lined by stratified squamous epithelia of varying thickness and level of keratinization. Most the oral mucosa is covered by a lining of non-keratinized epithelium (the floor of mouth being particularly thin and vascular). The areas related to mastication (hard palate, outer surface of gingiva) are partially keratinized epithelia, and the tongue is covered with a specialized epithelium that incorporates the taste buds. The gingival crevice is a particularly open and vulnerable site. It is lined by the sulcular epithelium that is non-keratinized and becomes progressively thinner, transitioning to the junctional epithelium which connects to the tooth surface and is constantly exposed to the microbial biofilm and experiences trauma, leading to constant immune activation.
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