Interactome Networks and Human Disease

Vidal, Marc; Cusick, Michael E.; Barabasi, Albert-Laszlo

doi:10.1016/j.cell.2011.02.016

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BioAcyl Corp

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Vidal, M., Cusick, M. E., & Barabasi, A.-L. (2011). Interactome Networks and Human Disease. Cell, 144(6), 986–998.
Added by: Dr. Enrique Feoli (17/01/2021, 02:34) Last edited by: Dr. Enrique Feoli (05/02/2021, 19:28)

Resource type: Journal Article
DOI: 10.1016/j.cell.2011.02.016
ID no. (ISBN etc.): 0092-8674
BibTeX citation key: Vidal2011
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Categories: BioAcyl Corp
Subcategories: Network Medicine
Creators: Barabasi, Cusick, Vidal
Collection: Cell

Views: 2/268

Abstract

Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.