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Kobayashi, A., Weinberg, V., Darragh, T., & Smith-McCune, K. (2008). Evolving immunosuppressive microenvironment during human cervical carcinogenesis. Mucosal Immunology, 1, 412–420. Added by: Dr. Enrique Feoli (19/09/2020, 19:33) Last edited by: Dr. Enrique Feoli (19/09/2020, 19:35) |
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| Resource type: Journal Article DOI: 10.1038/mi.2008.33 ID no. (ISBN etc.): 1935-3456 BibTeX citation key: Kobayashi2008 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Inmunidad de mucosas, Papilomavirus Creators: Darragh, Kobayashi, Smith-McCune, Weinberg Collection: Mucosal Immunology |
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| Abstract |
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Chronic infection with human papillomavirus (HPV) can result in cervical cancer. To understand how HPV escapes immune eradication, we examined biophenotypes of immune cells in human normal cervix, cervical intraepithelial neoplasia (CIN), and cancer. Expression and cellular localization of Forkhead box protein-3 (FOXP3), indolamine 2,3-dioxygenase (IDO), interleukin (IL)-10, and interferon (IFN)-γ were examined by immunofluorescence and immunohistochemistry. Mean cell densities of stromal FOXP3+ cells, IDO+ cells, IL-10+ cells, CD1a+ cells, and macrophages significantly increased from normal cervix to cancer, whereas densities of IFN-γ+ and MMP-9+ cells increased from normal cervix to CIN but decreased in cancer. Flow cytometry confirmed significant elevation of cervical T cells expressing IFN-γ and transforming growth factor-β in CIN compared with normal cervix. Upon activation, a significantly increased proportion of cervical T cells expressed IFN-γ in CIN than normal. A unique subset of morphologically immature stromal dendritic cells expressing IL-10 and IDO was more numerous in cancer than in normal cervix and CIN. The potentially suppressive immune milieu in the cervix may be permissive of HPV-associated cervical carcinogenesis.
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