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Panagioti, E., Klenerman, P., Lee, L. N., van der Burg, S. H., & Arens, R. (2018). Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections. Forntiers in immunology, 9. Added by: Dr. Enrique Feoli (17/07/2020, 10:42) Last edited by: Dr. Enrique Feoli (17/07/2020, 10:48) |
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| Resource type: Journal Article DOI: 10.3389/fimmu.2018.00276 ID no. (ISBN etc.): 1664-3224 BibTeX citation key: Panagioti2018 View all bibliographic details  |
Categories: Zotero Subcategories: Inmunidad de mucosas Creators: Arens, Klenerman, Lee, Panagioti, van der Burg Collection: Forntiers in immunology |
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| Abstract |
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For many years the focus of prophylactic vaccines was to elicit neutralizing antibodies but it has become increasingly evident that T cell-mediated immunity plays a central role in controlling persistent viral infections such as with HIV, CMV, and HCV. Currently, a variety of promising prophylactic vaccines, capable of inducing substantial vaccine-specific T cell responses, are investigated in preclinical and clinical studies. There is compelling evidence that protection by T cells is related to the magnitude and breadth of the T cell response, to the type and homing properties of the memory T cell subsets, and to their cytokine polyfunctionality and metabolic fitness. In this review, we evaluated these key factors that determine the qualitative and quantitative properties of CD4+ and CD8+ T cell responses in the context of chronic viral disease and prophylactic vaccine development. Elucidation of the mechanisms underlying T cell-mediated protection against chronic viral pathogens will facilitate the development of more potent, durable and safe prophylactic T cell-based vaccines.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
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Publisher: Frontiers in immunology
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