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Picard, M., & Shirihai, O. S. (2022). Mitochondrial signal transduction. Cell Metabolism, 34(11), 1620–1653. Added by: Dr. Enrique Feoli (04/07/2026, 20:32) Last edited by: Dr. Enrique Feoli (04/07/2026, 20:45) |
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| Resource type: Journal Article Published DOI: 10.1016/j.cmet.2022.10.008 ID no. (ISBN etc.): 1550-4131 BibTeX citation key: Picard2022 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Mitochondrial signaling Creators: Picard, Shirihai Collection: Cell Metabolism |
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| Abstract |
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The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are the processor of the cell, and together with the nucleus and other organelles they constitute the mitochondrial information processing system (MIPS). In a three-step process, mitochondria (1) sense and respond to both endogenous and environmental inputs through morphological and functional remodeling; (2) integrate information through dynamic, network-based physical interactions and diffusion mechanisms; and (3) produce output signals that tune the functions of other organelles and systemically regulate physiology. This input-to-output transformation allows mitochondria to transduce metabolic, biochemical, neuroendocrine, and other local or systemic signals that enhance organismal adaptation. An explicit focus on mitochondrial signal transduction emphasizes the role of communication in mitochondrial biology. This framework also opens new avenues to understand how mitochondria mediate inter-organ processes underlying human health.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
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The flow of information through the MIPS proceeds sequentially as follows: incoming signals are sensed by molecular receptors and biological structures on/within mitochondria (sensing), which exchange with each other molecular signals and labile states such as membrane potential via fusion/fission processes and other (non)physical interactions (integration), and which simultaneously release signaling factors such as metabolites, cofactors, proteins, nucleic acids, and heat that propagate information beyond the mitochondrial membranes (signaling). Figure 3 illustrates the repertoire of known mitochondrial substrates and mechanisms available for signal transduction. This broad repertoire emphasizes communication at different levels of biological organization, including protein-protein interactions (molecular), inter-organelle communication (sub-cellular organelles), autocrine or inter-cellular paracrine transfer (cells), and endocrine information transfer (organs and systems).
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
