Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing

Seegren, Philip V.; Downs, Taylor K.; Stremska, Marta E.

doi:10.1016/j.celrep.2020.108411

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BioAcyl Corp

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Seegren, P. V., Downs, T. K., & Stremska, M. E. (2020). Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing. Cell Reports, 33(8).
Added by: Dr. Enrique Feoli (20/05/2026, 15:31) Last edited by: Dr. Enrique Feoli (20/05/2026, 15:34)

Resource type: Journal Article
DOI: 10.1016/j.celrep.2020.108411
ID no. (ISBN etc.): 2211-1247
BibTeX citation key: Seegren2020
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Categories: BioAcyl Corp
Creators: Downs, Seegren, Stremska
Collection: Cell Reports

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Abstract

Phagocytes reallocate metabolic resources to kill engulfed pathogens, but the intracellular signals that rapidly switch the immunometabolic program necessary to fuel microbial killing are not understood. We report that macrophages use a fast two-step Ca2+ relay to meet the bioenergetic demands of phagosomal killing. Upon detection of a fungal pathogen, macrophages rapidly elevate cytosolic Ca2+ (phase 1), and by concurrently activating the mitochondrial Ca2+ (mCa2+) uniporter (MCU), they trigger a rapid influx of Ca2+ into the mitochondria (phase 2). mCa2+ signaling reprograms mitochondrial metabolism, at least in part, through the activation of pyruvate dehydrogenase (PDH). Deprived of mCa2+ signaling, Mcu?/? macrophages are deficient in phagosomal reactive oxygen species (ROS) production and defective at killing fungi. Mice lacking MCU in their myeloid cells are highly susceptible to disseminated candidiasis. In essence, this study reveals an elegant design principle that MCU-dependent Ca2+ signaling is an electrometabolic switch to fuel phagosome killing.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli

Notes

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The signaling mechanisms that rapidly reallocate metabolic resources to meet the bioenergetic demands of microbial killing are not understood. Seegren et al. show that mitochondrial Ca²⁺ signaling serves as a fast electrometabolic switch to fuel microbial killing by phagocytes. This study identifies the mitochondrial Ca²⁺ channel MCU as a critical component of cell-intrinsic antimicrobial responses.

Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli