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Zhao, J., Andreev, I., & Silva, H. M. (2024). Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity. Science Immunology, 9(94), eadd1967. Added by: Dr. Enrique Feoli (09/04/2026, 16:21) Last edited by: Dr. Enrique Feoli (09/04/2026, 16:22) |
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| Resource type: Journal Article DOI: 10.1126/sciimmunol.add1967 BibTeX citation key: Zhao2024 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Homeostasis Creators: Andreev, Silva, Zhao Collection: Science Immunology |
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| Abstract |
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Resident tissue macrophages (RTMs) encompass a highly diverse set of cells abundantly present in every tissue and organ. RTMs are recognized as central players in innate immune responses, and more recently their importance beyond host defense has started to be highlighted. Despite sharing a universal name and several canonical markers, RTMs perform remarkably specialized activities tailored to sustain critical homeostatic functions of the organs they reside in. These cells can mediate neuronal communication, participate in metabolic pathways, and secrete growth factors. In this Review, we summarize how the division of labor among different RTM subsets helps support tissue homeostasis. We discuss how the local microenvironment influences the development of RTMs, the molecular processes they support, and how dysregulation of RTMs can lead to disease. Last, we highlight both the similarities and tissue-specific distinctions of key RTM subsets, aiming to coalesce recent classifications and perspectives into a unified view. Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |