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Kuramoto, K., & He, C. (2022). Degradative and Non-Degradative Roles of Autophagy Proteins in Metabolism and Metabolic Diseases. Frontiers in Cell and Developmental Biology, Volume 10 - 2022. 
Added by: Dr. Enrique Feoli (05/04/2026, 20:17)   Last edited by: Dr. Enrique Feoli (05/04/2026, 20:20)
Resource type: Journal Article
DOI: 10.3389/fcell.2022.844481
ID no. (ISBN etc.): 2296-634X
BibTeX citation key: Kuramoto2022
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 Categories: BioAcyl Corp
Subcategories: Autophagy and mitophagy
Creators: He, Kuramoto
Collection: Frontiers in Cell and Developmental Biology		 Views: 4/4
Abstract
Autophagy is a stress-induced lysosomal degradation pathway regulated by evolutionarily conserved autophagy-related (ATG) genes. Recent research has revealed that autophagy plays an important role in the regulation of energy metabolism, development of metabolic tissues, and pathogenesis of metabolic disorders. Bulk and selective degradation by autophagy helps maintain protein homeostasis and physiological function of cells. Aside from classical degradative roles, ATG proteins also carry out non-classical secretory functions of metabolic tissues. In this review, we summarize recent progresses and unanswered questions on the mechanisms of autophagy and ATG proteins in metabolic regulation, with a focus on organelle and nutrient storage degradation, as well as vesicular and hormonal secretion. Such knowledge broadens our understanding on the cause, pathophysiology, and prevention of metabolic diseases including obesity and diabetes.
Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
Notes

FIGURE 2

Non-canonical functions of the autophagy machinery in vesicle trafficking and secretion. ATG proteins regulate systemic metabolic and energy balance via non-degradative functions in vesicle trafficking and secretory protein release, including adiponectin secretion through direct interaction between BECN1 and the exocyst protein (left), retromer-driven GLUT1 recycling and ATG5- and LC3-dependent exosome secretion through the endosomal and MVB pathway (middle), and secretory autophagy (right).


Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
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