BioAcyl Corp
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Krezalek, M. A., DeFazio, J., & Zaborina, O. (2016). The shift of an intestinal “microbiome” to a “pathobiome” governs the course and outcome of sepsis following surgical injury. Shock (Augusta, Ga.), 45(5), 475–482. Added by: Dr. Enrique Feoli (23/03/2026, 14:40) Last edited by: Dr. Enrique Feoli (23/03/2026, 14:41) |
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| Resource type: Journal Article DOI: 10.1097/SHK.0000000000000534 ID no. (ISBN etc.): 1073-2322 BibTeX citation key: Krezalek2016 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: SSI Creators: DeFazio, Krezalek, Zaborina Collection: Shock (Augusta, Ga.) |
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| Abstract |
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Sepsis following surgical injury remains a growing and worrisome problem following both emergent and elective surgery. Although early resuscitation efforts and prompt antibiotic therapy have improved outcomes in the first 24–48 hours, late onset sepsis is now the most common cause of death in modern intensive care units. This time shift may be, in part, a result of prolonged exposure of the host to the stressors of critical illness which, over time, erode the health promoting intestinal microbiota and allow for virulent pathogens to predominate. Colonizing pathogens can then subvert the immune system and contribute to the deterioration of the host response. Here we posit that novel approaches integrating the molecular, ecological and evolutionary dynamics of the evolving gut microbiome/pathobiome during critical illness are needed to understand and prevent the late onset sepsis that develops following prolonged critical illness.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |