BioAcyl Corp
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Ayres, J. S., & Schneider, D. S. (2008). Two ways to survive an infection: What resistance and tolerance can teach us about treatments for infectious diseases. Nature Reviews. Immunology, 8(11), 889–895. Added by: Dr. Enrique Feoli (09/03/2026, 11:30) Last edited by: Dr. Enrique Feoli (09/03/2026, 11:34) |
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| Resource type: Journal Article DOI: 10.1038/nri2432 ID no. (ISBN etc.): 1474-1733 BibTeX citation key: Ayres2008 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Disease Tolerance Creators: Ayres, Schneider Collection: Nature Reviews. Immunology |
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| Abstract |
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A host can evolve two types of defence mechanisms to increase its fitness when challenged with a pathogen – resistance and tolerance. Immunology is a well-defined field in which we dissect the mechanisms behind resistance to infection, but we tend to look at the ability to tolerate infections in a less methodical manner. In this Opinion article, we present the argument that animals have a specific suite of tolerance mechanisms (distinct from their resistance mechanisms), and highlight evidence for these defensive measures and discuss their potential clinical impact. It is important to distinguish between these two defence mechanisms because they have different pathological and epidemiological effects. Increased understanding of these defences could lead to more efficient treatments for infectious diseases and a better description of host–parasite interactions.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
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Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
