Topical prebiotic nitrate: can extending the ‘hang-time’ in the mouth improve oral-vascular health outcomes?

Green, Juliana; Green, Shawn J.

doi:10.1038/s41522-024-00527-3

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BioAcyl Corp

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Green, J., & Green, S. J. (2024). Topical prebiotic nitrate: Can extending the ‘hang-time’ in the mouth improve oral-vascular health outcomes? npj Biofilms and Microbiomes, 10(1), 57.
Added by: Dr. Enrique Feoli (22/02/2026, 19:28) Last edited by: Dr. Enrique Feoli (22/02/2026, 19:34)

Resource type: Journal Article
DOI: 10.1038/s41522-024-00527-3
ID no. (ISBN etc.): 2055-5008
BibTeX citation key: Green2024
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Categories: BioAcyl Corp
Subcategories: Entero-salivary cycle
Creators: Green, Green
Collection: npj Biofilms and Microbiomes

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Abstract

Both oral and systemic health outcomes may improve by simply extending the residence or ‘hang time’ of prebiotic nitrate formulations in the oral cavity. This may be particularly helpful in individuals where salivary flow of nitrate is limited, as in the case of dry mouth, or those with cardiometabolic complications that exhibit dysbiosis and low nitric oxide (NO) bioavailability because of poor dietary nitrate compliance. After 6 weeks of drinking 6.7 mM NO₃ beet juice daily, Velmurugan et al. observed improvement in endothelial function with a corresponding increase in Rothia mucilaginosa and Neisseria flavescens¹³.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli