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Torcellan, T., Friedrich, C., & Doucet-Ladevèze. (2024). Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection. Immunity, 57(1), 124–140. Added by: Dr. Enrique Feoli (23/12/2025, 19:11) Last edited by: Dr. Enrique Feoli (23/12/2025, 19:35) |
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| Resource type: Journal Article ID no. (ISBN etc.): 1074-7613 BibTeX citation key: Torcellan2024 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Microecoambiente, Microenvironment, NKCs Creators: Doucet-Ladevèze, Friedrich, Torcellan Publisher: Cell Press Collection: Immunity |
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| Abstract |
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Conventional natural killer (cNK) cells are short-lived, circulating innate lymphocytes. Torcellan, Friedrich et al. demonstrate that cNK cells differentiate into long-lived, memory-like, tissue-resident NK (trNK) cells upon acute infections of skin. These Tcf7hiCD69hi cells share similarities with CD56bright NK cells in human skin and mediate accelerated responses to secondary infection.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
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One striking finding from our study was the production of Areg by human and murine NK cells (Figure 3 and Figure 6C-E) and the unexpected role of NK cells in tissue repair (Figure 7). While other immune cells have been shown to play an important role in the repair of tissue after infection, such as ILCs and T cells65, 66, 67, this role has not been well elucidated for NK cells. The notion of NK cells as important for tissue integrity is supported by our data in which NK cell depletion after acute HSV-2 infection leads to increased tissue pathology (Figure 7). While it is known that NK cells are important during peak HSV-2 infection to manage viral control through production of IFNg20, 21, 22, we have shown that NK cells are also necessary after viral clearance to aid in restoration of tissue integrity. There have been other reports in models of inflammation that suggest NK cell depletion leads to increased epithelial damage and inflammation. Liu et al. demonstrate that in a model of corneal epithelial abrasion, NK cells modulate the inflammatory response in the eye and support wound healing. In their model, NK cell depletion led to an increased number of neutrophils in the wound and reduced epithelial cell division, leading to overall delayed wound healing68. In a model of allergic airway inflammation, depletion of NK cells led to delayed clearance of airway eosinophils and CD4 T-cells, leading to disruption of airway resolution69. It is possible that in addition to aiding in tissue repair through Areg production, NK cells also play an immunoregulatory function by the suppression of T cells in the VT. NK cells can regulate antiviral immune responses by direct elimination of activated CD4 T cells, thereby reducing inflammation in the tissue70, 71. We show that NK cell depletion after acute HSV-2 infection leads to increased immune infiltration in the tissue (Figure 7B-C), which could be due to unrestrained T cell proliferation. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |