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Sun, J. C., & Lanier, L. L. (2011). NK cell development, homeostasis and function: Parallels with CD8+ T cells. Nature Reviews. Immunology, 11(10), 645–657. Added by: Dr. Enrique Feoli (21/12/2025, 17:02) Last edited by: Dr. Enrique Feoli (21/12/2025, 17:04) |
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| Resource type: Journal Article DOI: 10.1038/nri3044 ID no. (ISBN etc.): 1474-1733 BibTeX citation key: Sun2011 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Microenvironment, NKCs Creators: Lanier, Sun Collection: Nature Reviews. Immunology |
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| Abstract |
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Natural killer cells survey host tissues for signs of infection, transformation, or stress, and true to their name, kill target cells that have become useless or are detrimental to the host. For decades, NK cells have been classified as a component of innate immunity. However, accumulating evidence in mouse and human suggests that, like T and B cells of adaptive immunity, NK cells are educated during development, possess antigen-specific receptors, undergo clonal expansion during infection, and generate long-lived memory cells. In this review, we will highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8+ T cell.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |