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Matsuzawa-Ishimoto, Y., Hwang, S., & Cadwell, K. (2018). Autophagy and Inflammation. Annual Review of Immunology, 36(Volume 36, 2018), 73–101. Added by: Dr. Enrique Feoli (01/12/2025, 22:00) Last edited by: Dr. Enrique Feoli (01/12/2025, 22:05) |
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| Resource type: Journal Article DOI: 10.1146/annurev-immunol-042617-053253 ID no. (ISBN etc.): 1545-3278 BibTeX citation key: MatsuzawaIshimoto2018 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Autophagy and mitophagy Keywords: autoimmune disease Creators: Cadwell, Hwang, Matsuzawa-Ishimoto Collection: Annual Review of Immunology |
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| Abstract |
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The cellular degradative pathway of autophagy has a fundamental role in immunity. Here, we review the function of autophagy and autophagy proteins in inflammation. We discuss how the autophagy machinery controls the burden of infectious agents while simultaneously limiting inflammatory pathologies, which often involves processes that are distinct from conventional autophagy. Among the newly emerging processes we describe are LC3-associated phagocytosis and targeting by autophagy proteins, both of which require many of the same proteins that mediate conventional autophagy. We also discuss how autophagy contributes to differentiation of myeloid and lymphoid cell types, coordinates multicellular immunity, and facilitates memory responses. Together, these functions establish an intimate link between autophagy, mucosal immunity, and chronic inflammatory diseases. Finally, we offer our perspective on current challenges and barriers to translation.
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| Notes |
The role of autophagy in immunity. Autophagy has critical functions in the development and function of immune cells, innate immune signaling, and cell-autonomous defense. The impairment of autophagy can mediate susceptibility to infectious and inflammatory diseases. (Bottom left) An H&E-stained section of the lung showing exacerbated pneumonia following intranasal lung infection of mice with impaired autophagy. Black arrowhead points to fibrin thrombus. Image is adapted from Maurer et al. (186). (Bottom right) An endoscopic image of the small intestine of a patient with Crohn disease (provided by Kazuo Ohtsuka, Kento Takenaka, and Yu Matsuzawa-Ishimoto). Abbreviations: APC, antigen-presenting cell; MAVS, mitochondrial antiviral signaling; ROS, reactive oxygen species; H&E, hematoxylin and eosin. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |