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Horst, V. D. D., Carter-Timofte, M. E., & Grevenynghe. (2022). Regulation of innate immunity by Nrf2. Current Opinion in Immunology, 78, 102247. Added by: Dr. Enrique Feoli (22/09/2025, 22:49) Last edited by: Dr. Enrique Feoli (22/09/2025, 22:51) |
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| Resource type: Journal Article DOI: 10.1016/j.coi.2022.102247 ID no. (ISBN etc.): 0952-7915 BibTeX citation key: Horst2022 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Disease Tolerance, Homeostasis Creators: Carter-Timofte, Grevenynghe, Horst Collection: Current Opinion in Immunology |
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| Abstract |
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The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly investigated as a regulator of redox homeostasis. However, research over the past years has implicated Nrf2 as an important regulator of innate immunity. Here, we discuss the role of Nrf2 in the innate immune response, highlighting the interaction between Nrf2 and major components of the innate immune system. Indeed, Nrf2 has been shown to widely control the immune response by interacting directly or indirectly with important innate immune components, including the toll-like receptors–Nuclear factor kappa B (NF-kB) pathway, inflammasome signaling, and the type-I interferon response. This indicates an essential role for Nrf2 in diseases related to microbial infections, inflammation, and cancer. Yet, further studies are required to determine the exact mechanism underpinning the interactions between Nrf2 and innate immune players in order to allow a better understanding of these diseases and leverage new therapeutic strategies.
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