BioAcyl Corp
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Aoi, W., Zou, X., & Xiao, J. B. (2020). Body fluid ph balance in metabolic health and possible benefits of dietary alkaline foods. eFood, 1(1), 12–23. Added by: Dr. Enrique Feoli (07/09/2025, 19:59) Last edited by: Dr. Enrique Feoli (07/09/2025, 20:04) |
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| Resource type: Journal Article DOI: 10.2991/efood.k.190924.001 BibTeX citation key: Aoi2020 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Disease Tolerance, Metabolic acidosis Keywords: diabetes, food, insulin resistance, interstitial fluid, pH Creators: Aoi, Xiao, Zou Collection: eFood |
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| Abstract |
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Living cells have several mechanisms to avoid acidic conditions created by excess protons. The protons are extruded to the extracellular space via the plasma membrane by various types of transporters such as the Na+/H+ exchanger and monocarboxylate transporters, which hereby contribute to the exclusion of protons in the cells of metabolic tissues including the liver, skeletal muscle, and adipose tissue. Disturbances in the functioning of the transporters cause abnormal intracellular fluid pH of the cells and dysfunction of metabolic homeostasis, leading to the development of metabolic diseases and a decrease in physical fitness level. In addition to the intracellular fluid pH regulation, growing evidence shows that the fluid pH in the interstitial space around metabolic tissues is easily reduced due to weaker pH buffering capacity than that in the cytosol and blood circulation. Therefore, pH reduction in the interstitial fluid may cause the onset of metabolic dysfunction. In contrast, several dietary foods have direct and indirect benefits in maintaining the interstitial fluid pH to the normal range by improving buffering capacities, suppressing proton production, and activating proton transporters, which strengthen the effect of appropriate diet on metabolic health.
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| Notes |
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Glucose metabolism impairment and interstitial pH reduction in skeletal muscle cells. Glucose and glycogen are used as major energy substrates. Excess glucose/glycogen utilization and aerobic metabolism impairment cause lactic acid production through the glycolysis pathway. Further, binding affinity of insulin to its receptor is diminished with pH reduction in interstitial fluid. This leads to suppression of insulin signaling activity and glucose uptake via Glucose Transporter 4 (GLUT4). Therefore, low interstitial fluid pH causes insulin resistance and hyperglycemia via diminution of insulin affinity to its receptor in skeletal muscle cells. IR, insulin receptor; IRS, insulin receptor substrate; PI3K, phosphoinositide-3-kinase; AS160, Akt substrate of 160 kDa; MCT, monocarboxylate transporter; NHE, Na+/H+ exchanger. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
