BioAcyl Corp
BioAcyl Corp |
|
 |
 |
 |
|
Soares, M. P., & Ribeiro, A. M. (2015). Nrf2 as a master regulator of tissue damage control and disease tolerance to infection. Biochemical Society Transactions, 43(4), 663–668. Added by: Dr. Enrique Feoli (02/09/2025, 20:42) Last edited by: Dr. Enrique Feoli (02/09/2025, 20:43) |
 |
| Resource type: Journal Article DOI: 10.1042/BST20150054 ID no. (ISBN etc.): 0300-5127 BibTeX citation key: Soares2015 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Disease Tolerance Creators: Ribeiro, Soares Collection: Biochemical Society Transactions |
Views: 3/19
|
| Abstract |
|
Damage control refers to those actions made towards minimizing damage or loss. Depending on the context, these can range from emergency procedures dealing with the sinking of a ship or to a surgery dealing with severe trauma or even to an imaginary company in Marvel comics, which repairs damaged property arising from conflicts between super heroes and villains. In the context of host microbe interactions, tissue damage control refers to an adaptive response that limits the extent of tissue damage associated with infection. Tissue damage control can limit the severity of infectious diseases without interfering with pathogen burden, conferring disease tolerance to infection. This contrasts with immune-driven resistance mechanisms, which although essential to protect the host from infection, can impose tissue damage to host parenchyma tissues. This damaging effect is countered by stress responses that confer tissue damage control and disease tolerance to infection. Here we discuss how the stress response regulated by the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) acts in such a manner.
|
| Notes |
|
\_eprint: https://portlandpress.com/biochemsoctrans/article-pdf/43/4/663/431285/bst0430663.pdf
|