BioAcyl Corp
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Martins, R., Carlos, A. R., & Braza, F. (2019). Disease Tolerance as an Inherent Component of Immunity. Annual Review of Immunology, 37(Volume 37, 2019), 405–437. Added by: Dr. Enrique Feoli (01/09/2025, 18:12) Last edited by: Dr. Enrique Feoli (02/09/2025, 01:49) |
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| Resource type: Journal Article DOI: 10.1146/annurev-immunol-042718-041739 ID no. (ISBN etc.): 1545-3278 BibTeX citation key: Martins2019 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Disease Tolerance Keywords: tissue damage control Creators: Braza, Carlos, Martins Collection: Annual Review of Immunology |
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| Abstract |
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Pathogenic organisms exert a negative impact on host health, revealed by the clinical signs of infectious diseases. Immunity limits the severity of infectious diseases through resistance mechanisms that sense and target pathogens for containment, killing, or expulsion. These resistance mechanisms are viewed as the prevailing function of immunity. Under pathophysiologic conditions, however, immunity arises in response to infections that carry health and fitness costs to the host. Therefore, additional defense mechanisms are required to limit these costs, before immunity becomes operational as well as thereafter to avoid immunopathology. These are tissue damage control mechanisms that adjust the metabolic output of host tissues to different forms of stress and damage associated with infection. Disease tolerance is the term used to define this defense strategy, which does not exert a direct impact on pathogens but is essential to limit the health and fitness costs of infection. Under this argument, we propose that disease tolerance is an inherent component of immunity.
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| Notes |
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Host-pathogen interactions are usually summarized by the activation of the host immune system by pathogens, triggering a response that provides resistance to infection. This does not take into consideration the different forms of stress and damage imposed on host parenchyma tissues, by pathogens (virulence) or immune-driven resistance mechanisms (immunopathology). The countervailing response to these processes, referred to as tissue damage control, underlies the establishment of disease tolerance to infection. Disease tolerance is inferred when variations between host health or fitness parameters occur independently of pathogen load over time, as revealed by the corresponding disease trajectories (223). Of note, tissue damage control limits immunopathology and therefore might enable resistance mechanisms to operate in a more robust or prolonged manner to reduce pathogen load. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
