Tissue damage control in disease tolerance

Soares, Miguel P.; Gozzelino, Raffaella; Weis, Sebastian

doi:10.1016/j.it.2014.08.001

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BioAcyl Corp

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Soares, M. P., Gozzelino, R., & Weis, S. (2014). Tissue damage control in disease tolerance. Trends in Immunology, 35(10), 483–494.
Added by: Dr. Enrique Feoli (01/09/2025, 18:04) Last edited by: Dr. Enrique Feoli (01/09/2025, 18:05)

Resource type: Journal Article
DOI: 10.1016/j.it.2014.08.001
ID no. (ISBN etc.): 1471-4906
BibTeX citation key: Soares2014
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Categories: BioAcyl Corp
Subcategories: Disease Tolerance
Keywords: damage response, disease tolerance, infection, stress response, tissue damage control
Creators: Gozzelino, Soares, Weis
Collection: Trends in Immunology

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Abstract

Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose here that tissue damage control underlies many of the protective effects of disease tolerance. We explore the mechanisms of cellular adaptation that underlie tissue damage control in response to infection as well as sterile inflammation, integrating both stress and damage responses. Finally, we discuss the potential impact of targeting these mechanisms in the treatment of disease.