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Holodick, N. E., Rodríguez-Zhurbenko, N., & Hernández, A. M. (2017). Defining Natural Antibodies. Frontiers in immunology, Volume 8 - 2017. Added by: Dr. Enrique Feoli (10/08/2025, 17:36) Last edited by: Dr. Enrique Feoli (10/08/2025, 22:18) |
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| Resource type: Journal Article DOI: 10.3389/fimmu.2017.00872 ID no. (ISBN etc.): 1664-3224 BibTeX citation key: Holodick2017 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp, BioAcyl Corp Subcategories: Innate Immunity, Mucosal Immunity, Natural Antibodies Creators: Hernández, Holodick, Rodríguez-Zhurbenko Collection: Frontiers in immunology |
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| Abstract |
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The traditional definition of natural antibodies (Nabs) states these antibodies are present prior to the body encountering cognate antigen providing a first line of defense against infection thereby, allowing time for a specific antibody response to be mounted. The literature has a seemingly common definition of NAbs; however, as our knowledge of antibodies and B cells is refined, re-evaluation of the common definition of natural antibodies may be required. Defining natural antibodies becomes important as the function of NAb production is used to define B cell subsets (1) and as these important molecules are shown to play numerous roles in the immune system (Figure 1). Herein, we aim to briefly summarize our current knowledge of NAbs in the context of initiating a discussion within the field of how such an important and multifaceted group of molecules should be defined.
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| Notes |
Overview of natural antibodies’ (NAbs) attributes. Graphical representation of the various NAb functions (outside green circle), epitope recognition (inside yellow circle), isotype (inside red circle), and cells shown to produce NAbs (inside blue circle). Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |