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Caputa, G., Matsushita, M., & Sanin, D. E. (2022). Intracellular infection and immune system cues rewire adipocytes to acquire immune function. Cell Metabolism, 34(8), 747–760. 
Added by: Dr. Enrique Feoli (03/08/2025, 23:58)   Last edited by: Dr. Enrique Feoli (04/08/2025, 00:01)
Resource type: Journal Article
ID no. (ISBN etc.): 1550-4131
BibTeX citation key: Caputa2022
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 Categories: BioAcyl Corp
Subcategories: Peer review
Keywords: adipocyte, IFN-γ, infection, iNK T cells, lymph node, Metabolism, NK cells, NOD1, NOS2, perinodal adipose tissue
Creators: Caputa, Matsushita, Sanin
Collection: Cell Metabolism		 Views: 2/16
Abstract

Highlights

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NK and iNKT cells make IFN-γ in response to bacterial infection in PAT
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IFN-γ induces NOD1-dependent iNOS expression in infected adipocytes
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Metabolic reprograming supports NO production in infected adipocytes
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Intrinsic NO production allows adipocytes to clear intracellular bacteria

Summary

Adipose tissue (AT) plays a central role in systemic metabolic homeostasis, but its function during bacterial infection remains unclear. Following subcutaneous bacterial infection, adipocytes surrounding draining lymph nodes initiated a transcriptional response indicative of stimulation with IFN-γ and a shift away from lipid metabolism toward an immunologic function. Natural killer (NK) and invariant NK T (iNKT) cells were identified as sources of infection-induced IFN-γ in perinodal AT (PAT). IFN-γ induced Nos2 expression in adipocytes through a process dependent on nuclear-binding oligomerization domain 1 (NOD1) sensing of live intracellular bacteria. iNOS expression was coupled to metabolic rewiring, inducing increased diversion of extracellular L-arginine through the arginosuccinate shunt and urea cycle to produce nitric oxide (NO), directly mediating bacterial clearance. In vivo, control of infection in adipocytes was dependent on adipocyte-intrinsic sensing of IFN-γ and expression of iNOS. Thus, adipocytes are licensed by innate lymphocytes to acquire anti-bacterial functions during infection

  
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