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Tang, X. (2023). Regenerating the heart by metabolically reprogramming the cardiomyocyte epigenome. Cell Metabolism, 35(11), 1849–1851. 
Added by: Dr. Enrique Feoli (21/07/2025, 23:54)   Last edited by: Dr. Enrique Feoli (21/07/2025, 23:59)
Resource type: Journal Article
DOI: 10.1016/j.cmet.2023.10.007
ID no. (ISBN etc.): 1550-4131
BibTeX citation key: Tang2023
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 Categories: BioAcyl Corp, BioAcyl Corp
Subcategories: Cardiac regeneration, Metabolic reprogramming
Creators: Tang
Collection: Cell Metabolism		 Views: 1/15
Abstract
In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration in adults is limited after cardiac injury. Recent work by Li et al. in Nature revealed that inhibition of fatty acid oxidation can rewire cell metabolism and lead to epigenetic reprogramming of cardiomyocytes to an immature state that facilitates cardiomyocyte cell-cycle reentry and heart regeneration in adult animals.
  
Notes

Regeneration of heart tissues

(A) Heart regeneration capacity, cardiomyocyte proliferative capacity, and proportion of polyploid cardiomyocytes across species. (B) Comparison of glycolysis, fatty acid oxidation, cardiomyocyte maturation, and cardiomyocyte proliferation rate in zebrafish, neonatal mice, adult mice, and humans. (C) Metabolic pattern, accumulation of α-KG, the activity of KDM5 and H3K4me3 marks, and expression of cardiomyocyte maturation gene signatures in embryo/neonatal, wild-type adult, and Cpt1b-KO adult hearts in mice.


Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
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