BioAcyl Corp
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Sen, C. K., Friday, A. J., & Roy, S. (2025). Cell and Tissue Reprogramming: Unlocking a New Era in Medical Drug Discovery. Pharmacological Reviews, 100077. Added by: Dr. Enrique Feoli (15/07/2025, 02:32) Last edited by: Dr. Enrique Feoli (16/07/2025, 18:06) |
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| Resource type: Journal Article DOI: 10.1016/j.pharmr.2025.100077 ID no. (ISBN etc.): 0031-6997 BibTeX citation key: Sen2025 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Cell plasticity, Cell reprogramming Creators: Friday, Roy, Sen Collection: Pharmacological Reviews |
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| Abstract |
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Recent advancements in cell and tissue biology have fundamentally changed our understanding of cellular behavior, revealing that both stem as well as non-stem cells exhibit remarkable plasticity and adaptability. This discovery has paved the way for revolutionary medical drug therapies that leverage cell and tissue reprogramming to repair or regenerate damaged tissues, offering new hope for conditions that were once considered irreversible. Tissue reprogramming involves the activation of specific molecular pathways to convert the function of residual tissue to compensate for the loss of tissue function to aging, trauma or disease processes. By targeting these pathways emerging drugs can promote regenerative processes, enabling the restoration of tissue function lost due to aging, injury, or disease. These therapies have shown promising results in preclinical studies addressing a wide range of diseases. Unlike traditional treatments, which focus primarily on managing symptoms, tissue reprogramming therapies offer a dynamic approach that can fundamentally alter cellular states, leading to functional recovery. This review explores the current state of cell and tissue reprogramming, highlighting its potential applications in regenerative medicine and the challenges that must be addressed for successful clinical translation. As our understanding of cellular plasticity continues to evolve, these innovative therapies stand at the forefront of a new era in medicine, with the potential to transform treatment paradigms and significantly improve patient outcomes across a wide range of conditions.
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