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Kelly, M. J., Breathnach, C., & Tracey, K. J. (2022). Manipulation of the inflammatory reflex as a therapeutic strategy. Cell Reports Medicine, 3(7). 
Added by: Dr. Enrique Feoli (26/06/2025, 21:57)   Last edited by: Dr. Enrique Feoli (26/06/2025, 22:11)
Resource type: Journal Article
BibTeX citation key: Kelly2022
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 Categories: BioAcyl Corp
Subcategories: Inflammatory reflex
Keywords: cholinergic anti-inflammatory pathway, inflammatory disease, inflammatory reflex, vagus nerve stimulation, α7 nicotinic acetylcholine receptor
Creators: Breathnach, Kelly, Tracey
Publisher: Cell Press
Collection: Cell Reports Medicine		 Views: 3/18
Abstract
The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a neural circuit through which the CNS can modulate peripheral immune responses. Signals communicated via the vagus and splenic nerves use acetylcholine, produced by Choline acetyltransferase (ChAT)+ T cells, to downregulate the inflammatory actions of macrophages expressing α7 nicotinic receptors. Pre-clinical studies using transgenic animals, cholinergic agonists, vagotomy, and vagus nerve stimulation have demonstrated this pathway’s role and therapeutic potential in numerous inflammatory diseases. In this review, we summarize what is understood about the inflammatory reflex. We also demonstrate how pre-clinical findings are being translated into promising clinical trials, and we draw particular attention to innovative bioelectronic methods of harnessing the cholinergic anti-inflammatory pathway for clinical use.

Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
Notes

Proposed intracellular mechanisms of the α7nAChR

AC6, adenylyl cyclase 6; Ach, acetylcholine; AMP, adenosine monophosphate; cAMP, cyclic adenosine monophosphate; CREB, cAMP response element-binding protein; JAK2, Janus kinase 2; MAPK, mitogen-activated protein kinase; miRNA, microRNA; NF-κB, nuclear factor κ-B; NLRP3, NOD-, LRR-, and pyrin domain-containing protein; STAT3, signal transducer and activator of transcription 3.


Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
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