From periphery to center stage: 50 years of advancements in innate immunity

Carpenter, Susan; O’Neill, Luke A. J.

doi:10.1016/j.cell.2024.03.036

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Carpenter, S., & O’Neill, L. A. J. (2024). From periphery to center stage: 50 years of advancements in innate immunity. Cell, 187(9), 2030–2051.
Added by: Dr. Enrique Feoli (10/06/2025, 22:33) Last edited by: Dr. Enrique Feoli (26/12/2025, 17:46)

Resource type: Journal Article
DOI: 10.1016/j.cell.2024.03.036
ID no. (ISBN etc.): 928674
BibTeX citation key: Carpenter2024
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Categories: BioAcyl Corp
Subcategories: Innate Immunity
Creators: Carpenter, O’Neill
Publisher: Elsevier Inc.
Collection: Cell

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Abstract

Over the past 50 years in the field of immunology, something of a Copernican revolution has happened. For a long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves the exquisitely specific activities of lymphocytes. But the other arm of immunity, so-called “innate immunity,” had been neglected. To celebrate Cell’s 50^th anniversary, we have put together a review of the processes and components of innate immunity and trace the seminal contributions leading to the modern state of this field. Innate immunity has joined adaptive immunity in the center of interest for all those who study the body’s defenses, as well as homeostasis and pathology. We are now entering the era where therapeutic targeting of innate immune receptors and downstream signals hold substantial promise for infectious and inflammatory diseases and cancer.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli

Notes

TLR signaling: plasma membrane-bound or endosomally localized TLRs signal through adaptors and kinases situated in the cytosol to drive inflammatory cytokines and type 1 interferon (IFN) responses. Inflammasome: the inflammasome is a multiprotein complex formed in the cytosol in response to microbial ligands or host danger signals. Activation leads to caspase-1 activity, cleavage, and release of IL-1β or IL-18. Nucleic acid sensing: DNA is recognized by cGAS within the cytosol, leading to the production of the second messenger cGAMP, which signals through STING to induce type 1 IFNs. RNA is sensed by RIG-I or MDA-5 to induce type I IFNs. Noncoding regulation: many families of noncoding RNAs including lncRNAs, tRNA fragments, miRNAs, and circRNAs have emerged as key regulators of biological processes including transcription, splicing, and translation, which can impact immunity.

Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli