BioAcyl Corp
BioAcyl Corp |
|
 |
 |
 |
|
Krezalek, M. A., & Alverdy, J. C. (2023). The Role of the Gut Microbiome on the Development of Surgical Site Infections. Clinics in Colon and Rectal Surgery, 36(2), 133–137. Added by: Dr. Enrique Feoli (01/04/2025, 19:53) Last edited by: Dr. Enrique Feoli (21/05/2025, 20:49) |
 |
| Resource type: Journal Article DOI: 10.1055/s-0043-1760719 ID no. (ISBN etc.): 1531-0043 BibTeX citation key: Krezalek2023 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Heridas quirúrgicas Creators: Alverdy, Krezalek Collection: Clinics in Colon and Rectal Surgery |
Views: 2/19
|
| Abstract |
|
Despite advances in antisepsis techniques, surgical site infection remains the most common and most costly reason for hospital readmission after surgery. Wound infections are conventionally thought to be directly caused by wound contamination. However, despite strict adherence to surgical site infection prevention techniques and bundles, these infections continue to occur at high rates. The contaminant theory of surgical site infection fails to predict and explain most postoperative infections and still remains unproven. In this article we provide evidence that the process of surgical site infection development is far more complex than what can be explained by simple bacterial contamination and hosts' ability to clear the contaminating pathogen. We show a link between the intestinal microbiome and distant surgical site infections, even in the absence of intestinal barrier breach. We discuss the Trojan-horse mechanisms by which surgical wounds may become seeded by pathogens from within one's own body and the contingencies that need to be met for an infection to develop.
|
| Notes |
The Trojan-horse mechanism of metastatic surgical site infections. The neutrophils continuously sample, survey, and scavenge the environment at mucosal borders of the gut. Once the bacterium finds itself in the neutrophil phagosome, it may express a dormant avirulent state, evading host's defenses. Microbe-carrying neutrophil returns to the circulation and then homes to the damaged tissues where it delivers its bacterial payload. The environment of the damaged tissue then cues the bacterium to express a virulent phenotype in a context-dependent manner that may result in an infection. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |