Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosacan be achieved without iron provision by maintaining local phosphate abundance: role of pH

Romanowski, Kathleen; Zaborin, Alexander; Fernandez, Hoylan

doi:10.1186/1471-2180-11-212

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BioAcyl Corp

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Romanowski, K., Zaborin, A., & Fernandez, H. (2011). Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosacan be achieved without iron provision by maintaining local phosphate abundance: Role of pH. BMC Microbiology, 11(1), 212.
Added by: Dr. Enrique Feoli (29/03/2025, 12:01) Last edited by: Dr. Enrique Feoli (29/03/2025, 12:04)

Resource type: Journal Article
DOI: 10.1186/1471-2180-11-212
ID no. (ISBN etc.): 1471-2180
BibTeX citation key: Romanowski2011
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Categories: BioAcyl Corp
Subcategories: Gut-origin Sepsis
Keywords: , , , ,
Creators: Fernandez, Romanowski, Zaborin
Collection: BMC Microbiology

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Abstract

During extreme physiological stress, the intestinal tract can be transformed into a harsh environment characterized by regio- spatial alterations in oxygen, pH, and phosphate concentration. When the human intestine is exposed to extreme medical interventions, the normal flora becomes replaced by pathogenic species whose virulence can be triggered by various physico-chemical cues leading to lethal sepsis. We previously demonstrated that phosphate depletion develops in the mouse intestine following surgical injury and triggers intestinal P. aeruginosa to express a lethal phenotype that can be prevented by oral phosphate ([Pi]) supplementation.