BioAcyl Corp
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Müller, W. E. G., Relkovic, D., & Ackermann, M. (2017). Enhancement of wound healing in normal and diabetic mice by topical application of amorphous polyphosphate. superior effect of a host–guest composite material composed of collagen (host) and polyphosphate (guest). Polymers, 9(7). Added by: Dr. Enrique Feoli (08/02/2024, 11:30) Last edited by: Dr. Enrique Feoli (08/02/2024, 11:38) |
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| Resource type: Journal Article DOI: 10.3390/polym9070300 ID no. (ISBN etc.): 2073-4360 BibTeX citation key: Muller2017 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Microenvironment, Wound Healing Creators: Ackermann, Müller, Relkovic Collection: Polymers |
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| Abstract |
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The effect of polyphosphate (polyP) microparticles on wound healing was tested both in vitro and in a mice model in vivo. Two approaches were used: pure salts of polyphosphate, fabricated as amorphous microparticles (MPs, consisting of calcium and magnesium salts of polyP, “Ca–polyp-MPs” and “Mg–polyp-MPs”), and host–guest composite particles, prepared from amorphous collagen (host) and polyphosphate (guest), termed “col/polyp-MPs”. Animal experiments with polyP on healing of excisional wounds were performed using both normal mice and diabetic mice. After a healing period of 7 days “Ca–polyp-MP” significantly improved re-epithelialization in normal mice from 31% (control) to 72% (polyP microparticle-treated). Importantly, in diabetic mice, particularly the host–guest particles “col/polyp-MP”, increased the rate of re-epithelialization to ≈40% (control, 23%). In addition, those particles increased the expression of COL-I and COL-III as well as the expression the α-smooth muscle actin and the plasminogen activator inhibitor-1. We propose that “Ca–polyp-MPs”, and particularly the host–guest “col/polyp-MPs” are useful for topical treatment of wounds.
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