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Wissinger, E., Goulding, J., & Hussell, T. (2009). Immune homeostasis in the respiratory tract and its impact on heterologous infection. Seminars in Immunology, 21(3), 147–155. Added by: Dr. Enrique Feoli (14/10/2023, 19:27) Last edited by: Dr. Enrique Feoli (14/10/2023, 19:28) |
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| Resource type: Journal Article Published DOI: https://doi.org/10.1016/j.smim.2009.01.005 ID no. (ISBN etc.): 1044-5323 BibTeX citation key: Wissinger2009 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Microenvironment Creators: Goulding, Hussell, Wissinger Collection: Seminars in Immunology |
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| Abstract |
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Innate immunity at mucosal surfaces requires additional restraint to prevent inflammation to innocuous antigens or commensal microorganisms. The threshold above which airway macrophages become activated is raised by site-specific factors including the receptors for transforming growth factor beta, interleukin 10 and CD200; the ligands for which are produced by, or expressed on, respiratory epithelium. We discuss such site-specific regulation and how this is continually altered by prior infections. Resetting of innate reactivity represents a strategy for limiting excessive inflammation, but in some may pre-dispose to secondary bacterial pneumonia.
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| Notes |
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Barrier Immunity
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