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Matsunaga, T., Sano, H., & Takita, K. (2023). Supersulphides provide airway protection in viral and chronic lung diseases. Nature Communications, 14(1), 4476. Added by: Dr. Enrique Feoli (08/08/2023, 11:53) Last edited by: Dr. Enrique Feoli (08/08/2023, 11:56) |
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| Resource type: Journal Article DOI: 10.1038/s41467-023-40182-4 ID no. (ISBN etc.): 2041-1723 BibTeX citation key: Matsunaga2023 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Supersulphides Creators: Matsunaga, Sano, Takita Collection: Nature Communications |
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| Abstract |
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Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulphide synthase (CPERS). Here, we identify protective functions of supersulphides in viral airway infections (influenza and COVID-19), in aged lungs and in chronic lung diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF). We develop a method for breath supersulphur-omics and demonstrate that levels of exhaled supersulphides increase in people with COVID-19 infection and in a hamster model of SARS-CoV-2 infection. Lung damage and subsequent lethality that result from oxidative stress and inflammation in mouse models of COPD, IPF, and ageing were mitigated by endogenous supersulphides production by CARS2/CPERS or exogenous administration of the supersulphide donor glutathione trisulphide. We revealed a protective role of supersulphides in airways with various viral or chronic insults and demonstrated the potential of targeting supersulphides in lung disease.
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Number: 1 Publisher: Nature Publishing Group
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