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Faenza, I., & Blalock, W. L. (2022). Innate immunity: A balance between disease and adaption to stress. Biomolecules, 12(5), 737. Added by: Dr. Enrique Feoli (29/06/2023, 18:41) Last edited by: Dr. Enrique Feoli (01/07/2023, 18:10) |
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| Resource type: Journal Article DOI: 10.3390/biom12050737 ID no. (ISBN etc.): 2218-273X BibTeX citation key: Faenza2022 View all bibliographic details  |
Categories: BioAcyl Corp, Innate immunity Subcategories: Innate Immunity Creators: Blalock, Faenza Collection: Biomolecules |
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| Abstract |
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Since first being documented in ancient times, the relation of inflammation with injury and disease has evolved in complexity and causality. Early observations supported a cause (injury) and effect (inflammation) relationship, but the number of pathologies linked to chronic inflammation suggests that inflammation itself acts as a potent promoter of injury and disease. Additionally, results from studies over the last 25 years point to chronic inflammation and innate immune signaling as a critical link between stress (exogenous and endogenous) and adaptation. This brief review looks to highlight the role of the innate immune response in disease pathology, and recent findings indicating the innate immune response to chronic stresses as an influence in driving adaptation.
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| Notes |
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The link between innate immune/inflammatory stress and DNA repair/modification may suggest that under conditions of constitutive/chronic stress, the immune response opens the door to a potential escape mechanism, allowing for enhanced mutation rates in the off-chance that an adaptation to the stress may be achieved [55,56,136,143] In an individual organism this may occur throughout one’s life, but how could such a mechanism favor transmission to subsequent generations? The effect of stress on offspring has long been reported in models such as fruitflies, C.elegans, and even birds [148,149,150], but recent data suggest that stress and inflammation also influence the methylation and epigenetic modification of gamete DNA, especially that of sperm [126,127,151]. In addition, stress and inflammation are bound to affect the mother and the environment of the developing fetus.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |