BioAcyl Corp
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Cronkite, D. A., & Strutt, T. M. (2018). The Regulation of Inflammation by Innate and Adaptive Lymphocytes. Journal of Immunology Research, 2018, 1467538. Added by: Dr. Enrique Feoli (25/06/2023, 20:19) Last edited by: Dr. Enrique Feoli (15/10/2023, 17:36) |
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| Resource type: Journal Article DOI: 10.1155/2018/1467538 ID no. (ISBN etc.): 2314-8861 BibTeX citation key: Cronkite2018 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp, Innate immunity Subcategories: Innate Immunity, Tcell types Cell-mediated effector immunity Creators: Cronkite, Strutt Collection: Journal of Immunology Research |
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| Abstract |
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Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear that some innate immune cells are epigenetically reprogrammed or “imprinted” by past experiences. These “trained” innate immune cells display altered inflammatory responses upon subsequent pathogen encounter. Remembrance of past pathogen encounters has classically been attributed to cohorts of antigen-specific memory T and B cells following the resolution of infection. During recall responses, memory T and B cells quickly respond by proliferating, producing effector cytokines, and performing various effector functions. An often-overlooked effector function of memory CD4 and CD8 T cells is the promotion of an inflammatory milieu at the initial site of infection that mirrors the primary encounter. This memory-conditioned inflammatory response, in conjunction with other secondary effector T cell functions, results in better control and more rapid resolution of both infection and the associated tissue pathology. Recent advancements in our understanding of inflammatory triggers, imprinting of the innate immune responses, and the role of T cell memory in regulating inflammation are discussed.
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| Notes |
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Memory T cells regulate inflammation at sites of infection. Traditional paradigms of innate instruction of adaptive immunity must now also appreciate that adaptive memory T cells regulate both the nature and shape of innate inflammatory responses. Memory CD4 T cell-mediated enhanced inflammatory responses are initiated independently of the classic PRR signaling and classic costimulatory molecule recognition and are better at containing virus than innate responses triggered in naïve hosts through PAMP-dependent mechanisms. |
